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NLM database Documents
Record 1 from database: MEDLINE
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- Title
- Studies on the chemical identity and biological functions of
pangamic acid.
- Author
- Schneider D; Helwig V; Staniek K; Nohl H; Elstner EF
- Address
- Lehrstuhl fÂur Phytopathologie, Labor fÂur Angewandte
Biochemie, Technische UniversitÂat MÂunchen,
Freising-Weihenstephan, Germany.
- Source
- Arzneimittelforschung, 1999 Apr, 49:4, 335-43
- Abstract
- Pangamic acid (6-O-(dimethylaminoacetyl)-D-gluconic acid) has
been detected 1938 and described as a natural, universally
occurring substance with multiple biological and medical
functions. In this respect pangamic acid has been worldwide on
the market since decades as a drug stimulating cellular
respiration. In addition to the natural pangamic acid,
diisopropylammonium dichloroacetate (DIPA), a synthetic product
not found in biological material, is on the market requesting
similar biological functions. In commercially available drugs on
the German market declared as pangamic acid three separate
substances can be found by chemical identification of pangamic
acid, namely: gluconic acid, glycine and diisopropylamonium
dichloroacetate. As biological functions have been found in
vitro inhibition of Cu-dependent LDL oxidation by glycine due to
chelation of Cu2+ ions and deterioration of mitochondrial
respiratory control due to an increased state IV oxygen
consumption rate at high concentrations of DIPA.
- Language of Publication
- English
- Unique Identifier
- 99269747
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- MeSH Heading (Major)
- Vitamin B Complex|*CH/*PD
- MeSH Heading
- Animal; Antioxidants|CH/PD; Cytochrome-c Oxidase|ME; Electron
Transport; Human; In Vitro; Lipoproteins, LDL|BL; Male;
Mitochondria, Liver|DE/EN/ME; Nuclear Magnetic Resonance;
Oxidation-Reduction; Photometry; Rats; Rats, Sprague-Dawley;
Spectrometry, Fluorescence; Spectrophotometry, Infrared
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0004-4172
- Country of Publication
- GERMANY
Record 2 from database: MEDLINE
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- Title
- The effect of pangamic acid on maximal treadmill performance.
- Author
- Gray ME; Titlow LW
- Address
-
- Source
- Med Sci Sports Exerc, 1982, 14:6, 424-7
- Abstract
- The effect of pangamic acid (calcium gluconate and N, N-Dimethylglycine)
ingestion was examined during short-term maximal treadmill
performance on 16 male track athletes. The study was conducted
as a double-blind experiment with an experimental group (E)
whose members each ingested six 50-mg pangamic acid tablets per
day and a control group (C) whose members each ingested six
placebo tablets per day for three weeks. The placebo tablets
were identical to the pangamic acid tablets in appearance.
Subjects were tested by using the Bruce treadmill protocol
before and after treatment. The following parameters were
examined: maximal heart rate (HR), treadmill time (TM), recovery
HR at minutes 1 and 3, and pre-test and post-test blood glucose
and lactate levels. Pre-treatment data were 183 bpm (E) and 194
bpm (C) for maximal HR, 16.99 min (E) and 16.49 min (C) for TM,
132.13 mg% (E) and 133.38 mg% (C) for post-test glucose, and
64.63 mg% (E) and 76.13 mg% (C) for post-test lactate.
Post-treatment data were 181 bpm (E) and 194 bpm (C) for maximal
HR, 17.21 min (E) and 16.83 min (C) for TM, 138.88 mg% (E) and
139.13 mg% (C) for post-test glucose, and 70.88 mg% (E) and
66.58 mg% (C) for post-test lactate. Multivariate analysis of
variance (MANOVA) revealed no significant differences (P greater
than 0.05) between groups after treatment. It was concluded that
ingestion of pangamic acid does not produce significant changes
in short-term maximal treadmill performance.
- Language of Publication
- English
- Unique Identifier
- 83140880
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- MeSH Heading (Major)
- Exertion|*DE; Vitamin B Complex|*PD
- MeSH Heading
- Adolescence; Adult; Blood Glucose|AN; Heart Rate|DE; Human;
Lactates|AN; Male; Support, Non-U.S. Gov't
- Publication Type
- CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
- ISSN
- 0195-9131
- Country of Publication
- UNITED STATES
Record 3 from database: MEDLINE
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- Title
- Critical evaluation of the current studies on pangamic
acid--vitamin B15.
- Author
- Lampart Szczapa E; Skupin J
- Address
-
- Source
- Nahrung, 1982, 26:4, 363-7
- Abstract
- The research on pangamic acid (vitamin B15) has been conducted
by specialists in many fields of science for along time. This,
however, has not put an end to controversies around the problem
of its therapeutic effect. The solution to the basic problems,
i.e. defining the compound structure, finding an explicit method
of its determination and identification as well as the evidence
of its biochemical and physiological functions in the human
organism appears as distant as ever. It has been found out,
however, that either some preparations referred to as pangamic
acid (vitamin B15) or their components may be detrimental to
man's health.
- Language of Publication
- English
- Unique Identifier
- 82272301
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- MeSH Heading (Major)
- Vitamin B Complex|AN/PH/PO/*TU
- MeSH Heading
- Chemistry; Human; Nutritional Requirements
- Publication Type
- JOURNAL ARTICLE; REVIEW
- ISSN
- 0027-769X
- Country of Publication
- GERMANY, EAST
Record 4 from database: MEDLINE
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- Title
- Vitamins and cancer prevention: issues and dilemmas.
- Author
- Young VR; Newberne PM
- Address
-
- Source
- Cancer, 1981 Mar, 47:5 Suppl, 1226-40
- Abstract
- Vitamins are a class of organic compounds that are components
of an adequate diet. They or their derivatives function as
coenzymes, cellular antioxidants, and/or regulators of gene
expression. Fourteen vitamins are recognized in human nutrition
(Vitamins A, D, E, K, B1, B2, B6, B12, C, niacin, folacin,
pantothenic acid, biotin, choline), with deficiencies or
excesses in intake leading to changes in protein, nucleic acid,
carbohydrates, fat and/or mineral metabolism. Thus, the
integrity of physiological systems, including those associated
with detoxification, cellular repair, immune processes, and
neural and endocrine function, depends upon the nutritional and
vitamin status of the host. For these reasons, it may be
anticipated that the adequacy of the vitamin supply to cells and
tissues would affect the development, progress, and outcome of
cancers. In this review, the definition and functions of and
requirements and recommended allowance for vitamins are
discussed briefly before exploring the evidence, largely from
studies in experimental animals, that indicates the nature of
the link between vitamins and cancer. Although evidence based on
studies in animal systems reveals that vitamin intake and status
can modulate the outcome of experimental carcinogenesis, the
findings are often conflicting and difficult to interpret.
Furthermore, it is not yet possible to develop a suitable
prediction of the role of the individual vitamins in tumor
development. The significance of these observations for human
nutrition and cancer prevention, particularly in reference to
ascorbic acid (vitamin C), vitamin E, and B-complex vitamins is
considered. Vitamin A and retinoid compounds are discussed
elsewhere in the symposium. The many popular misconceptions and
unsound advice concerning vitamins and health, including
"fake" vitamins-pangamic acid ("vitamin
B15") and laetrile ("vitamin B17")-are also
discussed. On the basis of current evidence, it would be
inappropriate to recommend either substantial changes in
habitual vitamin intakes, as provided by an adequate,
well-balanced diet, or promotion of megavitamin intakes, as a
means of reducing risk from cancers in the human population.
However, a prudent approach toward diet and food habits, as a
means of better optimizing the health consequences of our
complex lifestyle is to be recommended.
- Language of Publication
- English
- Unique Identifier
- 81209772
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- MeSH Heading (Major)
- Neoplasms|*PC; Vitamins|*
- MeSH Heading
- Advertising; Consumer Participation; Human; Nutrition|ED
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0008-543X
- Country of Publication
- UNITED STATES
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