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NLM database Documents
Record 1 from database: MEDLINE
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- Title
- Critical evaluation of the current studies on pangamic
acid--vitamin B15.
- Author
- Lampart Szczapa E; Skupin J
- Address
-
- Source
- Nahrung, 1982, 26:4, 363-7
- Abstract
- The research on pangamic acid (vitamin B15) has been conducted
by specialists in many fields of science for along time. This,
however, has not put an end to controversies around the problem
of its therapeutic effect. The solution to the basic problems,
i.e. defining the compound structure, finding an explicit method
of its determination and identification as well as the evidence
of its biochemical and physiological functions in the human
organism appears as distant as ever. It has been found out,
however, that either some preparations referred to as pangamic
acid (vitamin B15) or their components may be detrimental to
man's health.
- Language of Publication
- English
- Unique Identifier
- 82272301
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- MeSH Heading (Major)
- Vitamin B Complex|AN/PH/PO/*TU
- MeSH Heading
- Chemistry; Human; Nutritional Requirements
- Publication Type
- JOURNAL ARTICLE; REVIEW
- ISSN
- 0027-769X
- Country of Publication
- GERMANY, EAST
Record 2 from database: MEDLINE
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- Title
- Vitamins and cancer prevention: issues and dilemmas.
- Author
- Young VR; Newberne PM
- Address
-
- Source
- Cancer, 1981 Mar, 47:5 Suppl, 1226-40
- Abstract
- Vitamins are a class of organic compounds that are components
of an adequate diet. They or their derivatives function as
coenzymes, cellular antioxidants, and/or regulators of gene
expression. Fourteen vitamins are recognized in human nutrition
(Vitamins A, D, E, K, B1, B2, B6, B12, C, niacin, folacin,
pantothenic acid, biotin, choline), with deficiencies or
excesses in intake leading to changes in protein, nucleic acid,
carbohydrates, fat and/or mineral metabolism. Thus, the
integrity of physiological systems, including those associated
with detoxification, cellular repair, immune processes, and
neural and endocrine function, depends upon the nutritional and
vitamin status of the host. For these reasons, it may be
anticipated that the adequacy of the vitamin supply to cells and
tissues would affect the development, progress, and outcome of
cancers. In this review, the definition and functions of and
requirements and recommended allowance for vitamins are
discussed briefly before exploring the evidence, largely from
studies in experimental animals, that indicates the nature of
the link between vitamins and cancer. Although evidence based on
studies in animal systems reveals that vitamin intake and status
can modulate the outcome of experimental carcinogenesis, the
findings are often conflicting and difficult to interpret.
Furthermore, it is not yet possible to develop a suitable
prediction of the role of the individual vitamins in tumor
development. The significance of these observations for human
nutrition and cancer prevention, particularly in reference to
ascorbic acid (vitamin C), vitamin E, and B-complex vitamins is
considered. Vitamin A and retinoid compounds are discussed
elsewhere in the symposium. The many popular misconceptions and
unsound advice concerning vitamins and health, including
"fake" vitamins-pangamic acid ("vitamin
B15") and laetrile ("vitamin B17")-are also
discussed. On the basis of current evidence, it would be
inappropriate to recommend either substantial changes in
habitual vitamin intakes, as provided by an adequate,
well-balanced diet, or promotion of megavitamin intakes, as a
means of reducing risk from cancers in the human population.
However, a prudent approach toward diet and food habits, as a
means of better optimizing the health consequences of our
complex lifestyle is to be recommended.
- Language of Publication
- English
- Unique Identifier
- 81209772
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- MeSH Heading (Major)
- Neoplasms|*PC; Vitamins|*
- MeSH Heading
- Advertising; Consumer Participation; Human; Nutrition|ED
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0008-543X
- Country of Publication
- UNITED STATES
Record 3 from database: MEDLINE
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- Title
- Chemoprevention of colorectal cancer.
- Author
- Langman M; Boyle P
- Address
- Department of Medicine, Queen Elizabeth Hospital, Birmingham
B15 2TH, UK.
- Source
- Gut, 1998 Oct, 43:4, 578-85
- Abstract
- Colorectal cancer is the fourth commonest form of cancer in
men with 678 000 estimated new cases per year worldwide,
representing 8.9% of all new cancers. The disease is most
frequent in Occidental countries and particularly so in North
America, Australia, New Zealand, and parts of Europe. Prospects
for colorectal cancer control are bright and a number of
possible approaches could prove fruitful. Among these,
pharmaceutical measures seem to be valid and logical approaches
to the prevention of colorectal cancer and diminishing its
impact. Such approaches could concentrate in primary prevention
in at-risk subjects or be applied in altering the course of
precursor or established disease. Treatments used must fulfil
basic requirements of biological plausibility and safety in
continued use in large numbers of subjects. Those available
include vitamins and minerals, and other drugs with potential as
antioxidants, immune modulators or promoters of cell
differentiation or apoptosis. Of the various regimens suggested,
vitamin A supplementation may even predispose to adverse
outcomes, and antioxidant vitamins in general have no coherent
body of evidence to support their use. N-acetylcysteine and
ursodeoxycholic acid have promising characteristics but there
are as yet no clinical data to support the use of the former in
gut epithelial cancer, and formal dose ranging studies must be
carried out before the latter is submitted to large scale trial.
Folate shows promising characteristics but non-steroidal
anti-inflammatory drugs and vitamin D seem the most promising
agents. Both seem to reduce the incidence of disease, and to
reduce growth rates and/or induce differentiation or apoptosis
in gut epithelial cancer cells. Both are also well understood
pharmacologically. They may be preferred to newer selective
compounds in the same class until these newer compounds are
confirmed as safe for widespread long term use.
- Language of Publication
- English
- Unique Identifier
- 99071235
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- MeSH Heading (Major)
- Anti-Inflammatory Agents, Non-Steroidal|*TU; Antineoplastic
Agents|*TU; Colorectal Neoplasms|*PC; Histamine H2 Antagonists|*TU;
Vitamins|*TU
- MeSH Heading
- Decision Making; Human; Male; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0017-5749
- Country of Publication
- ENGLAND
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