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sulfur
MSM:
DMSO After 20 years
by
Stanley W. Jacob and Robert Herschler
Department of Surgery
Oregon Health Science University
Portland, Oregon
MSM, an odorless essentially tasteless, white crystalline chemical, demonstrates usefulness as a dietary supplement in men and lower animals.
Our research suggests that a minimum concentration in the body may be critical to both normal function and structure. Limited studies suggest that the systemic concentration of MSM drops in mammals with increasing age.
This may be due to dietary habits where one ingests foods with lower MSM potential with maturity or possibly there is a change in the renal threshold. Healthy juvenile rabbits maintain a level at or above 1 ppm [part per million] body weight, with milk being the dominant food and source. Cow's milk normally contains between 2 and 6 ppm MSM, dependent on source and freshness.
In an adult man, the circulating concentration varies but may average about 0.20 - 0.25 ppm. We have no estimate of total body concentration as yet, but suspect that MSM is banked in some of the organs, other than the adrenals.
Based on radiolabel (35 S) studies, the residence time of a single challenge in mammals may be several weeks with gradual dumping via the renal system. Daily output of urine contains several milligrams of MSM. This possibly is not the dominant excretory route. The following abnormal conditions seen in the clinic have responded to oral MSM generally administered at dosage levels of 250-270 mg/day. (Footnote #25)
Response to allergy:
Oral MSM moderates diverse allergic responses as to pollen and foods. Antiallergy medication and dissemination methods may be sharply reduced.
Control of hyperacidity:
Subjects that are chronic users of various antacids and histamine H2 receptor antagonists prefer MSM by reason of relief obtained coupled with freedom from serious, untoward effects.
Hypersensitivity to drugs:
Subjects demonstrating drug hypersensitivity to aspirin, several nonsterioid antiarthritic agents (Naprosy, Indocin, Motria), and oral antibiotics, were drug tolerant when MSM was given within an hour before or concurrent with the sensitizing drug
Control of constipation:
Particularly in the older population seen in our clinic, chronic constipation can be a medical problem of concern.
To date, over 50 subjects presenting chronic constipation have gained prompt and continuing relief by supplementing the diet with 100 to 500 mg of MSM per day.
We have seen some individuals with severely restricted lung function. Of these, only a few cooperated in vital function assessments.
All cooperated in endurance measurements. Limited objective and strong subjective evidence suggests that MSM is a useful dietary supplement to reduce lung dysfunction.
Anti-parasitic action:
In vitro and in vivo tests suggest MSM has an activity against a variety of medically important parasitic tracts, MSM, for example, is active against Giardia, Trichomondads, and round worms.
MSM presents a blocking interface between host and parasite. We are at present evaluating the action of MSM with a variety of abnormal or medical problems to determine whether any are responsive to a diet supplemented by MSM.
We are intrigued by the fact that MSM is a contestant factor in all normal diets of vertebrates and somewhat mystified by the seeming need of the body of adults for a concentration level above that available from a diet presumed as normal.
We hope soon to have data defining any specific interacting role that MSM may have with the water-soluble vitamins, particularly Vitamin C, which like MSM is reportedly banked in the adrenals. (Footnote #26)
It is not possible to directly compare DMSO and derivative MSM, though of the same chemical family.
Each is unique unto itself. MSM is a dietary factor derivable from most natural foods. It is conveniently taken alone or in foods. Taken by mouth, there is no after-breath.
DMSO has certain unpleasant attributes not possessed by MSM. While MSM is a dietary factor, DMSO is not. DMSO readily penetrates the dermas and less complicated membrane systems while MSM does not. Each contributes to the well being of mankind, but in differing ways. Both have important implications.
--as reported in the Journal of the New York Academy of Sciences
Jack O. Hyle Ph.D., P.M.D., P.C.
MSM
I. The Patients - 170 volunteers
A. Arthritis
1. Rheumatoid - 120
2. Osteo -------- 28
B. Bursitis ------------ 15
C. Allergy ------------- 4
D. Emphysema ---------1
E. Dogs-----------------2
II. Administered
Each patient was given five (5) teaspoons laboratory grade MSM.
Instructions: Dissolve one (1) level teaspoon of MSM in a small glass of water, drink quickly. If results within 30 hours, do not take again until needed. If no results within 30 hours, take as above every other day.
III. The Results
A. 129/170 - mild-to-dramatic pain relief
B. 41/170 - no change
IV. Discussion
A. MSM alone is excellent for pain relief.
B. The patients that MSM "did not work," seemed to have a blocking effect from standard arthritic drugs.
Burn victim, Bill Rich, discovered MSM for himself when a veterinarian friend had him try MSM.
Bill explains that his skin was flat, purple and leathery, up and down a majority of the right side of his body. After only a few days of taking MSM, Bill noticed an increase of stamina and energy, and over time an astonishing effect on his scarred skin as it started to turn pink and fill in.
Now Bill has little more than a small section of skin that is still barely detectable after having more than 60 feet of skin graft scars. After years of using MSM and helping others, Bill Rich lectures on the benefits of MSM. If you get a cassette tape about MSM it may well be Bill Rich talking.
When the body replaces old skin cells, if there is a deficiency of MSM, the new cells can be stiff and contribute to wrinkling.
MSM supplementation can help the body replace bad cells with good, healthy, elastic cells. Over time, wrinkles can go away, and brown and black spots and skin tumors can flow away as new cells replace the bad. Spider veins have disappeared!
It is the MSM in Aloe Vera leaves that sooths and repairs skin that has been cut, scraped, burned or damaged. The body then is able to repair the skin with the proper raw materials.
Thus, MSM is even more basic than Aloe Vera for this usage. This explains why only "fresh" Aloe Vera has the beneficial effect.
Perhaps 20% of the population may experience negative detoxification symptoms in the first 1-10 days during which toxins are flushed from the system, depending on the quantity of MSM they use.
Symptoms may include diarrhea, skin rash and/or possible headache along with several days of fatigue. In general, the more intense the symptoms the more toxins there are in the body and the more MSM is needed for detoxification.
As with all detoxifying actions, you will have to be the judge as to whether you go slowly or rapidly. If you take small amounts of MSM, you’ll probably notice nothing very dramatic.
If you take larger amount, particularly during the first several days, you may well experience whatever toxic reactions your body has stored up for you.
These toxic reactions can seem so "normal" that you just think you are "sick," so when you start with MSM, on heavy doses, you should drink LOTS of water and make sure you get plenty of sleep. These two actions will speed the detoxifying activity and allow you to feel better faster.
To reduce toxic symptoms (if you suspect Candida or metals) start with a lower dose of 750 mg twice a day and build up to 3,000 mg twice a day. Otherwise for a maximum benefit, it’s recommended to use an initial "load" dose of 3,000 mg twice a day. This dose can be safely continued indefinitely for maximum results). After initial treatment, physical energy levels should increase.
A single dose of MSM is usually not effective in ameliorating symptoms. Noticeable results are usually seen within 2 to 21 days. The minimum individual dose is about 750-1,000 mg. However, total daily dosages of 1,500 to 5,000 mg are recommended (2,500 to 5,000 mg being preferable).
The benefit of MSM will further be enhanced when 2,000 mg or more of Vitamin C is consumed. My recommended formula for oral chelation includes 4,500 mg of vitamin C per day. MSM would be an excellent additional nutrient to take with the oral chelation formula because it would complement it in many ways.
Subjects with chronic to sever allergies to environmental materials such as house dust, pollen, wool animal hair, feathers, and other diverse allergens report substantial to complete relief of their allergy symptoms. Allergy symptoms ranged from respiratory congestion to inflammation, itching, mucoid discharges, and general discomfort.
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